硕士生导师、教授名单

杨海涛

发布时间：2014-07-16浏览次数：6149

杨海涛（教授）

Email : yanght@cczu.edu.cn

研究方向:

  1. 近年来围绕“新方法、新结构、新反应”开展绿色有机合成方法学的研究，机理具有较强的创新性。系统研究基于酮肟酯类化合物实现各类含新型氮杂环的高效构建，合成的新结构吲哚、吡咯酮类等杂环化合物有着潜在的生物活性。

  2. 药物合成、农药、香料等有机化合物的工艺开发及改进。

教育经历:

  1. 2001年9月～2006年12月：中国科学技术大学化学系有机化学专业(硕、博)。

  2. 1996年9月～2000年7月： 安徽大学化学系应用化学专业；

工作经历：

  1. 2006.12-至今：常州大学石油化工学院

  2. 2011.3～2011.8，加拿大国家研究所生化所（NRC-IBS），访问学者，从事神经氨酶抑制剂的合成。


代表性科研项目:

  1. 2022.5-2023.6，酒石酸伐尼克兰的合成工艺开发，常州四药制药有限公司，主要负责人；

  2. 2018.7-2021.12，江苏省自然科学金面上项目，基于CDC反应合成α-氨基酸及构建多环螺吲哚的研究，BK20181462，主要负责人；

  3. 2019.12-2020.12，MCC和MBQ的合成技术路线和工艺开发，常州四药制药有限公司，主要负责人；

  4. 2019.11-2020.03，双缩酮制备醋酸乌立妥环氧物，常州四药制药有限公司，主要负责人；

  5. 2012.12-2015.12，基于[4+1]或[2+2]或[3+2]反应构建杂环的新方法研究，国家自然科学基金，212020111，主要负责人；

  6. 2009.12-2012.12，江苏省自然科学金，新型1，4－二氢吡啶钙离子通道阻滞剂的设计合成和筛选，BK2009543，主要负责人；

  7. 2014.12-2016.12，碘试剂作用下富勒烯衍生化新方法研究，江苏省自然科学基金面上项目，项目编号BK20141171，项目负责人；

  8. 2009.12-2012.12，富勒烯参与的自由基新反应研究，国家自然科学基金（青年）项目批准号20902039，项目负责人。


代表性论文：

  1. Xian-Heng Ding, Hui Li, Zhen Cui, Cang-Hai Yu, Wen-Ya Xu, En-Jun Qiao, Wan-Bo Jin, Xinyu Lyu,  Chun-Bao Miao,* and Hai-Tao Yang*,Org. Lett.2025, 27,6157−6162.

  2. Zhen Cui, Hui Li, Xian-Heng Ding, Cang-Hai Yu, En-Jun Qiao, Wan-Bo Jin, Wen-Ya Xu, Xinyu Lyu, Chun-Bao Miao,* and Hai-Tao Yang*,Org. Lett. 2025, 27, 5578−5583.

  3. Zi-Jun Hu, etal，Chun-Bao Miao,* and Hai-Tao Yang*，Iron-Catalyzed Double Annulation of OAcyl Oximes with Fumaronitrile for the Synthesis of 4Cyano-7-azaindoles，Org. Lett. 2024, 26, 4229−4234.

  4. Hai-Tao Yang,* Su-Qing Zhou, Dan-Mei Chen, Zi-Jun Hu, Xiao-Qi Qiang, Xiao-Qing Song, Sheng Tan, Wei-Hua Jiang, Yong-Qiang Sun, Chun-Bao Miao,* “Copper-Catalyzed Annulation of O Acyl Oximes with Cyclic 1,3-Diones for the Synthesis of 7,8-Dihydroindolizin-5(6H) ones and Cyclohexanone-Fused Furans”,Org. Lett.2023, 25, 838-842.

  5. Chun-Bao Miao,* Xiao-Qi Qiang, Xiaoli Xu, Xiao-Qing Song, Su-Qing Zhou, Xinyu Lyu, Hai-Tao Yang,* “Synthesis of Stable N-H Imines with a Benzo[7,8]indolizine Core and Benzo[7,8]indolizino[1,2-c]quinolines via Copper-Catalyzed Annulation of α,β-Unsaturated O-Acyl Ketoximes with Isoquinolinium N-Ylides”,Org. Lett.2022, 24, 3828-3833.

  6. Chun-Bao Miao,* Hong-Rong Guan, YiHan Tang, Kun Wang, Wen-Long Ren, Xinyu Lyu, Changsheng Yao, Hai-Tao Yang,* “Copper-Catalyzed Bisannulations of Malonate-Tethered O Acyl Oximes with Pyridine, Pyrazine, Pyridazine, and Quinoline Derivatives for the Construction of Dihydroindolizine-Fused Pyrrolidinones and Analogues”,Org. Lett.2021, 23, 8699-8704.

  7. Kun Wang, Hong-Rong Guan, Wen-Long Ren, Hai-Tao Yang,* Chun-Bao Miao,* “Copper-Catalyzed Cascade Annulation of Malonate-Tethered O Acyl Oximes with Cyclic 1,3-Dicarbonyl Compounds for the Synthesis of Spiro-Pentacyclic Derivatives”, J. Org. Chem. 2021, 86, 12309-12317.

  8. Li-Jin Zhou, Kun Wang, Hong-Rong Guan, An-Qi Zheng, Hai-Tao Yang,* and Chun-Bao Miao,* “Cu(OAc)2 Promoted Oxidative Cross-Dehydrogenative Coupling Reaction of α Acylmethyl Malonates with Indole Derivatives to Access 3 Functionalized Indoles and Polycyclic Indoles”,J. Org. Chem. 2020, 85, 7925-7938.

  9. Chun-Bao Miao,* An-Qi Zheng, Li-Jin Zhou, Xinyu Lyu, and Hai-Tao Yang,* “Copper-Catalyzed Annulation of Oxime Acetates with α Amino Acid Ester Derivatives: Synthesis of 3 Sulfonamido/Imino 4 Pyrrolin-2-ones”,Org. Lett.2020, 22, 3381-3385.

  10. Peng-Fei Mao, Li-Jin Zhou, An-Qi Zheng, Chun-Bao Miao,* Hai-Tao Yang,* “Cu(OAc)2 Triggered Cascade Reaction of Malonate-Tethered Acyl Oximes with Indoles, Indole-2-alcohols, and Indole-2-carboxamides”,Org. Lett.2019, 21, 5882-5885.

  11. Yong-Jian Liu, Jie Ge, Chun-Bao Miao, Hai-Tao Yang,* “Copper-Catalyzed Reaction of C60 with Tertiary Amines for the Preparation of Spiro-Linked Methanofullerenes and Fullerenoalkanals”,J. Org. Chem. 2019, 84, 6134-6142.

  12. Qiaoqiao Teng, Yi-Chen Tan, Chun-Bao Miao, Xiao-Qiang Sun, Hai-Tao Yang,* “Tunable Copper-Catalyzed Reaction of C60 with 2-Ethoxycarbonylacetamides and Subsequent BF3•Et2O-Mediated Isomerization of the Generated Dihydrofuran-Fused Fullerenes to Fulleropyrrolidinones”,J. Org. Chem. 2018, 83, 15268-15276.

  13. He Wu, Yan-Fang Sun, Chen Zhang, Chun-Bao Miao, Hai-Tao Yang,* “A facile method for the preparation of carbodiimides from thioureas and (Boc)2O”,Tetrahedro Lett.2018, 59, 739-742.

  14. Hai-Tao Yang,* Jie Ge, Xin-Wei Lu, Xiao-Qiang Sun, Chun-Bao Miao, “Copper-Catalyzed Functionalizations of C60 with Amino Alcohols”,J. Org. Chem.2017, 82, 5873-5880.

  15. Qi Meng,* Jun-Yu Chen, Chun-Bao Miao, Xiao-Qiang Sun, Hai-Tao Yang,* “Lewis base-catalyzed double nucleophilic substitution reaction of N-tosylaziridinofullerene with thioureas or guanidines”,Tetrahedron Lett.2017, 58, 2566-2570.

  16. Hai-Tao Yang,* Yi-Chen Tan, Jie Ge, He Wu, Jia-Xing Li,* Yang Yang, Xiao-Qiang Sun, Chun-Bao Miao,* “Reaction of C60 with Inactive Secondary Amines and Aldehydes and the Cu(OAc)2 Promoted Regioselective Intramolecular C−H Functionalization of the Generated Fulleropyrrolidines”,J. Org. Chem.2016, 81, 11201-11209.

  17. Hai-Tao Yang,* Yi-Chen Tan, Yang Yang, Xiao-Qiang Sun, Chun-Bao Miao, “Cu(OAc)2-Mediated Reaction of C60 with Ureas for the Preparation of Fulleroimidazolidinones”,J. Org. Chem.2016, 81, 1157-1163.

  18. Xin-Wei Lu, Meng-Lei Xing, Chun-Bao Miao, Jia-Xing Li, Xiao-Qiang Sun,* Hai-Tao Yang,* “Cu(OAc)2-promoted reaction of [60]fullerene with primary amines or diamines”,Org. Biomol. Chem.2015, 13, 8405-8410.

  19. Hai-Tao Yang,* Xin-Wei Lu, Meng-Lei Xing, Xiao-Qiang Sun, Chun-Bao Miao,*“Hypervalent Iodine Reagent Mediated Diamination of [60]Fullerene with Sulfamides or Phosphoryl Diamides”,Org. Lett.2014, 16, 5882-5885.

  20. Meng-Lei Xing, Xin-Wei Lu, Chun-Bao Miao, Jia-Xing Li, Xiao-Qiang Sun, Hai-Tao Yang,* “Lewis Base-Catalyzed Reaction of Aziridinofullerene with Ureas for the Preparation of Fulleroimidazolidinones”,J. Org. Chem.2014, 79, 11774-11779.

  21. Hai-Tao Yang,* Meng-Lei Xing, Xin-Wei Lu, Jia-Xing Li, Jiang Cheng, Xiao-Qiang Sun, Chun-Bao Miao, “BF3·Et2O- or DMAP-Catalyzed Double Nucleophilic Substitution Reaction of Aziridinofullerenes with Sulfamides or Amidines”,J. Org. Chem.2014, 79, 11744-11749.

  22. Hai-Tao Yang,* Meng-Lei Xing, Ye-Fei Zhu, Xiao-Qiang Sun, Jiang Cheng, Chun-Bao Miao, Fa-Bao Li,* “BF3Et2O-Catalyzed Formal [3+2] Reaction of Aziridinofullerenes with Carbonyl Compounds”,J. Org. Chem.2014, 79, 1487-1492.

  23. Chun-Bao Miao,* Xin-Wei Lu, Ping Wu, Jiaxing Li, Wen-Long Ren, Meng-Lei xing, Xiao-Qiang Sun, Hai-Tao Yang,* “Hypervalent Iodine Reagent-Mediated Reaction of [60]Fullerene with Amines”,J. Org. Chem.2013, 78, 12257-12262.

  24. Hai-Tao Yang,* Xi-Chen Liang, Yan-Hong Wang, Yang Yang, Xiao-Qiang Sun,* Chun-Bao Miao, “CuCl2-Mediated the Reaction of [60]Fullerene with Amines in the Presence or Absence of Dimethyl Acetylenedicarboxylate: Preparation of Fulleropyrroline or Aziridinofullerene Derivatives”,J. Org. Chem.2013, 78, 11992-11998.

  25. Hai-Tao Yang,* Wen-Long Ren, Chun-Ping Dong, Yang Yang, Xiao-Qiang Sun, Chun-Bao Miao,* “PhI(OAc)2/I2-mediated [3+2] reaction of [60]fullerene with amides for the preparation of fullerooxazoles”,Tetrahedron Lett.2013, 54, 6799-6803.

  26. Hai-Tao Yang,* Xi-Chen Liang, Yan-Hong Wang, Yang Yang, Xiao-Qiang Sun,* Chun-Bao Miao, “CuI-Catalyzed Oxidative [3+2] Reaction of Fullerene with Amidines or Amides Using Air as the Oxidant: Preparation of Fulleroimidazole or Fullerooxazole Derivatives”,Org. Lett.2013, 15, 4650-4653.

  27. Hai-Tao Yang,* Wen-Long Ren, Chun-Bao Miao, Chun-Ping Dong, Yang Yang, Hai-Tao Xi, Qi Meng, Yan Jiang, Xiao-Qiang Sun,* “DMAP-Catalyzed [3+2] and [4+2] Cycloaddition Reactions between [60]fullerene and Unmodified Morita–Baylis–Hillman Adducts in the Presence of Ac2O”,J. Org. Chem.2013, 78, 1163-1170.

  28. Hai-Tao Yang,* Wen-Long Ren, Xiao-Jiao Ruan, Zong-Yong Tian, Xi-Chen Liang, Chen Han, Xiao-Qiang Sun,* Chun-Bao Miao, “Reaction of [60]fullerene with α-alkoxyl/acyloxyl/phenolyl ketoxime: unusual C-C and C-O bond cleavage”,Tetrahedron Lett.2013, 54, 1428-1431.

  29. Hai-Tao Yang,* Zong-Yong Tian, Xiao-Jiao Ruan, Min Zhang, Chun-Bao Miao, Xiao-Qiang Sun,* “CuBr/PMDETA-Mediated Reactions of [60]Fullerene with Active Halides: Preparation of Methano[60]fullerene Derivatives”,Eur. J. Org. Chem.2012, 4918-4922.

  30. Chun-Bao Miao,* Min Zhang, Zong-Yong Tian, Hai-Tao Xi, Xiao-Qiang Sun, Hai-Tao Yang,*“Base-Controlled Selective Conversion of Michael Adducts of Malonates with Enones in the Presence of Iodine”,J. Org. Chem.2011, 76, 9809-9816.


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